(i) to keep workplace and environmental exposure to any physical, chemical or biological agent to the lowest practicable level;

(ii) to exercise engineering control measures at source and to supplement these with appropriate personal protective clothing and equipment when necessary;

(iii) to test adequately and maintain control measures and equipment;

(iv) to test, when necessary for the presence of viable process organisms outside the primary physical containment;

(v) to provide training of personnel;

(vi) to establish biological safety committees or subcommittees as required;

(vii) to formulate and implement local codes of practice for the safety of personnel.

2. In addition to these principles, the containment measures set out in Annex IV shall be applied, as appropriate, to contained uses of genetically modified micro-organisms in Group II so as to ensure a high level of safety.

3. The containment measures applied shall be periodically reviewed by the user to take into account new scientific or technical knowledge relative to risk management and treatment and disposal of wastes.