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            COVID-19-101           | 
                  
            A randomized, placebo-controlled trial, to evaluate the safety and immunogenicity of the COVID-19 vaccine, a measles vector-based vaccine candidate against COVID-19 in healthy volunteers consisting of an unblinded dose escalation and a blinded treatment p           | 
                  
                  
            Humans           | 
                  
            Recombinant measles virus vaccine strain (Schwarz strain) expressing the Spike glycoprotein 1 from SARS-CoV2           | 
              
          
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            Only notified under the "contained use" procedure. Dossier submitted on 20/08/2018.           | 
                  
            A Phase I/II study of the safety and efficacy of a single dose of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells in subjects with severe sickle disease           | 
                  
                  
            Humans           | 
                  
            Modified cells expressing Hemoglobin F (HbF)           | 
              
          
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            B/BE/07/BVW1           | 
                  
            Phase 1b and Phase 2a clinical trials with an hIL-10-expressing Lactococcus lactis           | 
                  
                  
            Humans           | 
                  
            Gene coding for the human interleukin-10 (hIL-10)           |