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            Only notified under the "contained use" procedure. Dossier submitted on 07/04/2017.           | 
                  
            Phase 1 clinical trial evaluation of two genetically modified vaccines against poliovirus           | 
                  
                  
            Humans           | 
                  
            Genetic modifications of the nOPV2 vaccine candidates aimed at stabilizing the genetic sequence against reversion compared to the Sabin-2 strain, nOPV2 candidate 1 (S2/cre5/S15domV/rec1/hifi3), nOPV2 candidate 2 (S2/S15domV/CpG40)           |