A Phase 1, Multicenter, Open-label Trial to Evaluate the Safety of Talimogene

EU record number

B/BE/16/BVW1

EudraCT number

2014-005386-67

Treated organism

Humans

Indication category

Treatment of hepatocellular carcinoma (HCC) and metastatic liver tumors (non-HCC)

Genetic modification

Insertion of a gene expressing granulocyte-macrophage colony-stimulating factor (hGM-CSF) - Functional deletion of two genes (ICP34.5 and ICP47) of the HSV-1 genome

Method of transfer of nucleic acid of interest

Herpes simplex virus 1 (HSV-1)

Route of administration

Intrahepatic injection

Locations in Belgium

UCL Cliniques Universitaires Saint Luc (Bruxelles), Universitair Ziekenhuis Gent, Universitair Ziekenhuis Leuven Campus Gasthuisberg, Universitair Ziekenhuis Antwerpen